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Integrated Structural Biology Grenoble

Contact person(s) related to this article / FAVIER Adrien

National and European platform of NMR

Presentation

The NMR platform at IBS, in partnership with CRMN Lyon, is part of the Rhone-Alpes Large-Scale NMR facility RALF-NMR, which provides access to high-end spectrometers for national and European users.

The 950 MHz spectrometer of the IBS is part of the national federation IR-RMN (Très Grande Instrumentation de Recherche). It allows academic researchers based in France to access high field spectrometers and the scientific expertise of the NMR labs involved in this network.

The NMR spectrometers of the IBS are also part of iNEXT, a European network of research infrastructures for providing access and technological advances in bio-NMR for European academic researchers within the RALF-NMR platform.

Key-words

1D 2D 3D NMR, high magnetic field, 3D structure and dynamics of biomolecules, fast acquisition methods.

Contact

Adrien FAVIER
Alicia VALLET

Dedicated staff

Adrien FAVIER

Specific equipments

  • 950 MHz Bruker with sample changer
  • Liquid probe:
    • Cryo TCI (1H, 13C, 15N, 2H), 5 mm, z-gradients
  • Solid probes:
    • MAS (1H, 13C, 15N), 3,2 mm, E-free (νr < 25 kHz)
    • MAS (1H, 13C, 15N), 1,3 mm, ( νr < 60 kHz)
    • MAS (1H, 13C, 15N), 0,7 mm, ( νr < 110 kHz)
  • 850 MHz Bruker with sample changer
  • Liquid probes:
    • Cryo TCI (1H, 13C, 15N, 2H), 5 mm, z-gradients
    • Cryo TCI (1H, 13C, 15N, 2H), 1,7 mm , z-gradients
  • 700 MHz Bruker
  • Liquid probe:
    • Cryo QCI (1H/31P, 13C, 15N, 2H), 5 mm, z-gradients
  • Solid probes:
    • MAS (1H, 13C, 15N), 3,2 mm, E-free
    • MAS (1H, 13C, 15N), 1,3 mm
  • 600 MHz Bruker
  • Liquid probe:
    • Cryo TCI (1H, 13C, 15N, 2H), 5 mm, x,y,z-gradients
  • 600 MHz Bruker
  • Liquid probe:
    • QCI (1H/19F, 13C, 15N, 2H), 5 mm, z-gradients
  • Solid probes
    • MAS (1H, 13C, 15N), 3,2 mm
    • MAS (1H, 13C, 15N, 31P), 1,3 mm
  • 600 MHz Agilent
  • Liquid probe:
    • penta (1H/31P, 13C, 15N, 2H), 5 mm, z-gradients
  • Solid probes
    • MAS (1H, 13C, 15N), 3,2 mm
    • MAS (1H, 13C, 15N), 1,6 mm, +z-gradients
  • Quality control of the spectrometers’ specifications is done quaterly and a standard sample is used in case of dysfunction.

Links to Websites

http://www.ir-rmn.fr/ (national)
http://http://www.ralf-nmr.fr/ RALF-NMR website

Access mode

Academics

Cost

Free of charge (TGIR-RMN / EU-NMR pay for travel costs and accommodation)

Location

IBS / NMR group

How to make a request ?

Through the IR-RMN web site: http://www.ir-rmn.fr/ for national users and http://www.ralf-nmr.fr for European users.
The applicants write a proposal online which is evaluated by a scientific committee.

Credits

In the general case users must aknowledge the platform in their publications: "This work used the platforms of the Grenoble Instruct-ERIC center (ISBG ; UMS 3518 CNRS-CEA-UGA-EMBL) within the Grenoble Partnership for Structural Biology (PSB), supported by FRISBI (ANR-10-INBS-05-02) and GRAL, financed within the University Grenoble Alpes graduate school (Ecoles Universitaires de Recherche) CBH-EUR-GS (ANR-17-EURE-0003), and with financial support from the TGIR-RMN-THC Fr3050 CNRS."
And depending on your way of access you must add one of the 2 acknowledgements below :
Bio-NMR users:
"Financial support by the Access to Research Infrastructures activity in the 7th Framework Programme of the EC (Project number: 261863, Bio-NMR) for conducting the research is gratefully acknowledged"
TGIR-RMN users:
"Financial support from the TGE RMN THC Fr3050 for conducting the research is gratefully acknowledged."