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Integrated Structural Biology Grenoble
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Contacts relatifs à cet article / MATHIEU Eric / ROYANT Antoine

The FIP Beamline


FIP2-BM07 is the French ESRF beamline for protein crystallography. FIP2 is the former FIP-BM30A beamline, which has moved to port BM07 between 2019 and 2021 due to the ESRF upgrade. FIP benefits from a strong upgrade of the optics (repolished mirrors, coders on all moving axes) and a modern Pilatus 6M detector.
FIP2 can be used either for single or multi-wavelength diffraction (SAD, MAD) experiments. Its optics deliver a focused beam on a fixed sample position, with an energy resolution of about 10-3 to 10-4 and a large accessible energy range (5-25 keV). The beam intensity is 1e12 photons/(0.3x0.3 mm2).

FIP2 is a highly automated beamline, with a unique robotized experiment setup. Indeed, apart the robotized sample changer, FIP possesses also a plate screening system (G-Rob) for direct in situ analysis of crystals in the X-ray beam. With this system, it is possible to analyze crystals in sitting drop crystallization plates or microchips. This is specifically interesting for crystals too small to be fished, or too fragile to be handled or frozen. A rapid screening to determine the nature of the object to be analyzed (salt or protein crystals), collecting few frames for cell determination, or even complete data collection are possible.

Key words

protein crystallography, anomalous phasing


Antoine Royant

Dedicated staff

  • 7 permanent staff (C. Brezin, P. Jacquet, Y. Sallaz-Damaz, F. Borel, P. Israel-Gouy, E. Mathieu, A. Royant),
  • 5 local-contacts : 2 scientists from the “Synchrotron group”, and 3 scientists coming from other IBS groups

Specific equipment

FIP2 is a bending-magnet beamline with :

  • symmetrical fixed exit optics : 2 mirrors and a double monochromator with cryogenic cooling and sagittal focusing).
  • an experimental setup comprising : a MD2 goniometer with on-axis camera and mini-kappa, a Pilatus 6M detector, a Rontec MCA counter, a sample changer robot with the possibility to screen crystals directly in their crystallization plate.


Access mode

FIP2 is accessible to :

  • French academic users, through a national program committee,
  • European academic users, through the ESRF scientific review committee,
  • industrial users (direct access, no selection process, limited to a 10% quota).


The access to FIP2-BM07 is free for academic users, and fee-based (rate fixed by the ESRF) for industrial users.


FIP2-BM07 is located at the ESRF, on bending magnet #07.

How to make a request ?

For French users and industrials, follow the common procedure FIP/Soleil :(
For European users, follow the standard ESRF application procedure